Definition and clinical description
Symptoms and prevalence
Diarrhoea occurs after a normal neonatal period, sometimes after weaning and/or the introduction of cow’s milk protein. It is hydro-electrolytic, abundant and often contains blood and mucus. It is often associated with signs of exudative enteropathy (anaemia, hypoalbuminaemia) and extra-digestive manifestations (especially IPEX).
Sometimes associated pathologies are present. These are extra-digestive autoimmune manifestations that precede, accompany or follow diarrhoea, they may be either clinical (insulin-dependent diabetes, hypothyroidism, tubulointerstitial and glomerular nephropathy, hepatitis, polyarthritis, haemolytic anaemia, thrombocytopaenia) or biological.